Amide addition reaction

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S337000

Reexamination Certificate

active

07880011

ABSTRACT:
A method of making a compound of formula IIcomprising the reaction of a compound of formula RCONH2with a compound of formula IIIR being a moiety having between 1 and 15 carbon atoms and optionally from 1 to 5 heteroatoms independently selected from oxygen, nitrogen and sulfur, and X and Y being independently selected front the group consisting of H, methyl, ethyl, OMe, OEt, and mixtures thereof; the reaction being performed in a solvent in the presence of a base.The method is useful for the inexpensive manufacture of certain commercially-valuable compounds, including some that have desirable cooling properties.

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Magnus, G., et al., “The Pyridylethylation of Active Hydrogen Compounds V. The Reaction of Ammonia, Certain Amines, Amides and Nitriles With 2-and 4-Vinylpyricdine and 2-Methyl-5-Vinylpyridine”, Journal of American Chemical Society, Aug. 20, 1956, pp. 4127-4129, vol. 78, American Chemical Society, Washington, D.C., U.S.
PCT/CH2008/000325-International Search Report, Sep. 29, 2008.

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