AMIDASE

Details AMIDASE AMIDASE

1997-10-15

2000-10-24

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435228, 435230, 435 691, 4352523, 4353201, 530350, 536 232, 536 237, C12N 978, C12N 980, C12N 120, C07H 2104

Patent

active

061365831

ABSTRACT:
A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or `natural` enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionality, a step which is very difficult to achieve with nonenzymatic methods.

REFERENCES:
patent: 5190875 (1993-03-01), Steinke et al.
patent: 5451522 (1995-09-01), Queener et al.
patent: 5494796 (1996-02-01), Spears et al.

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