Amidase

Details Amidase Amidase

1996-06-17

1999-03-02

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352523, 4353201, 435 691, 435228, 435230, 536 231, 536 232, 536 237, 530350, C12N 978, C12N 120, C12P 2106, C07H 2102

Patent

active

058770011

ABSTRACT:
A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or `natural` enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionality, a step which is very difficult to achieve with nonenzymatic methods.

REFERENCES:
patent: 5451522 (1995-09-01), Queener et al.
patent: 5494796 (1996-02-01), Spears et al.

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