Amico acid derivatives cyclized at the C-terminal

Details Amico acid derivatives cyclized at the C-terminal Amico acid derivatives cyclized at the C-terminal

1991-07-12

1993-09-14

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 87, 546143, 546146, 546147, 548495, 548496, A61K 3140, C07D20914

Patent

active

052449157

ABSTRACT:
Novel .alpha.-substituted Trp dipeptoid derivatives cyclized at the C-terminal useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds of the invention are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the compounds as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the compounds in diagnostic compositions.

REFERENCES:
patent: 4814463 (1989-03-01), Kim
patent: 4877785 (1989-10-01), Hanson et al.
patent: 4888427 (1989-12-01), Bodor
patent: 4987130 (1991-07-01), Tsushima et al.

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