Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1999-06-03
2000-02-08
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
A61K 3848
Patent
active
060225394
ABSTRACT:
A method of treating an individual suffering from Peyronie's disease. Collagenase is injected into a fibrous Peyronie's plaque in the penis of the individual suffering from the disease. The penis immediately after injection, is immobilized and maintained immobile for several hours. The collagenase is in a pharmaceutically acceptable carrier in a concentration of about 20,000 to about 40,000 ABC units per ml., and the amount and concentration of the collagenase is effective to soften and/or rupture the plaque whereby the erectile deviation caused by the plaque is ameliorated
REFERENCES:
patent: 4338300 (1982-07-01), Gelbard
M. K. Gelbard, et al. Collagenase for Peyronie's Disease . . . Urology Research (1982) 10: 135-140.
M. K. Gelbard, et al. The Use of Collagenase in the Treatment of Peyronie's Disease, J. of Urology, v. 134, p. 280-283 (Aug. 1985).
R. G. Hamilton et. al. Humoral Immune Response in Peyron Disease Patients Receiving . . . J. Urology (Mar. 1986) v. 135, pp. 641-647.
M. K. Gelbard, "Controlled Vacuum . . . Deformity" Urology (Oct. 1990) v. 36, #4. pp. 367-369.
F. Bernard, et. al. "Arterial Evaluation . . . " in J. Rajfer Common Problems in Infertility and Impotence, Chicago. Year Book Medical Publishers 1990 p 258-265.
M. K. Gelbard, et. al. Collagenase Versus . . . in Treatment of Peyro J Urology, (Jan. 1993) v. 149 pp. 56-58.
Advance Biofactures of Curacao
Plottel Roland
Upham John D.
Witz Jean C.
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