Ameliorant of cerebral circulation and optical isomer of NB-818,

Details Ameliorant of cerebral circulation and optical isomer of NB-818, Ameliorant of cerebral circulation and optical isomer of NB-818,

1994-07-29

1995-08-22

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546321, A61K 3144, C07D21190

Patent

active

054440777

ABSTRACT:
An ameliorant of cerebral circulation which contains 2-carbamoyloxymethyl-4-(2,3-dichlorophenyl )-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester as an active ingredient.

REFERENCES:
Br. J. Pharmac., 60, 35-43 (1977).
Patent Abst. of Japan, vol. 9, No. 301 (C-316) [2024], Nov. 28, 1985; & JP-A-60 139,671 (Banyu Seiyaku K.K.) 24 Jul. 1985.
Drugs of the Future, vol. 14, No. 4, 1989, pp. 331-333; "NB-818".
Japan J. Pharmacol., vol. 40, 1986, pp. 399-409; J. Nagaura et al.: "Cardiovascular effects of NPK-1886, a new dihydropyridine compound with calcium entry blocking activity".
Clinical Pharmacy, vol. 6, Apr. 1987, pp. 292-306, American Society of Hospital Pharmacists, Inc. C. M. Quandt, et al.: "Current concepts in clinical therapeutics: Ischemic cerebrovascular disease" *Page 303, right-hand column, lines 12-34*.
Acta Pharmacol. Et Toxicol., vol. 57, suppl. II, 1985, pp. 31-43; K.-E. Anderson: "Some extra-cardiac effects of diltiazem and other calcium entry blockers" *P. 33, section Cerebral arterial system* (1985).
"Archives internat . . . Therapie," vol. 297--Nos. 1/2 Jan./Feb. 1989.
"Archives internat . . . Therapie," vol. 291--Nos. 1/2 Jan./Feb. 1988.
"Life Sciences," vol. 43, 1715-1723 (1988).
"Journal of Pharm. & Exp. Thera.," vol. 246, No. 2 (1988) Nishikibe et al.
Ohtomo, Japanese Pharmacology and Therapeutics, vol. 20, No. 9 (1992) pp. 125-148.

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