Amebiasis vaccine

Details Amebiasis vaccine Amebiasis vaccine

1989-12-29

1991-04-02

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, 424 93, 530396, A61K 3902, A61K 3900

Patent

active

050046080

ABSTRACT:
Purified Gal/GalNAc adherence lectin of Entamoeba histolytica is used for development of a vaccine to prevent human amebiasis.

REFERENCES:
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Sharma; A., Infection and Immunity, Jun. 1985, pp. 634-637.
Kobiler; D., Infection and Immunity, vol. 29, No. 1, pp. 221-225, Jul. 1980.
Moss; B., Nature, vol. 311, Sep. 6, 1984, p. 67.
Petri et al., "Pathogenic and Nonpathogenic Strains of Entamoeba histolytica Can Be Differentiated by Monoclonal Antibodies to the Galactose-Specific Adherence Lectin", Infection and Immunity, 58:6, pp. 1802-1806 (U.S.A. 1990).
Petri et al., "Monoclonal Antibodies Directed Against the Galactose-Binding Lectin of Entamoeba histolytica Enhance Adherence", The Journal of Immunology, 144:12, pp. 4803-4809 (U.S.A. 1990).
Ravdin et al., The Role of Adherence on Cytopathogenic Mechanisms of Entamoeba histolytica, Study with Mammalian Tissue Culture Cells and Human Erythrocytes, J. Clin Invest, 68:1305-1313 (1981), U.S.A.
Ravdin et al., N-Acetyl-D-Galactosamine inhibitable Lectin of Entamoeba histolytica, I. Partial Purification and Relations to Amoebic in vitro, J.Infect Dis, 151: 804-815 (1985), U.S.A.
Salata et al., The N-Acetyl-D-Galactosamine Inhibitable Lectin of Entamoebia histolytica, II, Mitogenicity for Human Lymphocytes, J. Infect Dis, 151: 816-822 (1985), U.S.A.
Ravdin et al., Adherence of Entamoeba histolytica Trophozoites to Rat and Human Colonic Mucosa., Infect Immun, 48:292-297 (1985), U.S.A.
Ravdin, J. I., Pathogenesis of Disease Caused by Entamoeba histolytica: Studies of Adherence, Secreted Toxins, and Contact-Dependent Catalysis, Rev Infect Dis, 8:247-260 (1986), U.S.A.
Salata et al., Patients Treated for Amebic Liver Abscess Develop Cell-Mediated Immune Responses Effective in vitro Against Entamoeba histolytica, J. Immunol, 136: 2633-2639 (1986), U.S.A.
Salata et al., Review of the Human Immune Mechanisms Directed Against E. histolytica, Rev Infect Dis, 8:261-272 (U.S.A.) (1986).
Salata et al., The Interaction of Human Neutrophils and Entamoeba histolytica Trophozoites Increases Cytopathogenicity for Liver Cell Monolayers, J Infect Dis, 154:19-26 (1986), U.S.A.
Ravdin et al., Production of Mouse Monoclonal Antibodies which Inhibit in vitro Adherence of Entamoeba histolytica Trophozoites, Infect Immun, 53:1-5 (1986), U.S.A.
Petri et al., Characterization of the Membrane and Soluble Forms of the Adherence Lectin of Entamoeba histolytica, Abstract #41, Presented Dec. 8-11 (1986), Denver, Colo.
Petri et al., Adherence Mechanisms of Entamoeba histolytica: The N-Acetyl-D-Galactosamine Inhibitable Lectin, Clin Res, 34:222A (1986), U.S.A.
Petri et al., Isolation of the Adherence Lectin of Entamoeba histolytica, Clin Res, 34:529A (1986), U.S.A.
Chadee et al., Binding of Purified Rat Colonic Muchs to the Gal/GalNAc Adherence Lectin of Entamoeba histolytica, Clin Res, 34:438A (1986), U.S.A.

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