Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-06-26
2007-06-26
Carlson, Karen Cochrane (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S007100
Reexamination Certificate
active
11200904
ABSTRACT:
Disclosed is a method for identifying substances that alter the interaction of a presenilin protein with a presenilin-binding protein, including contacting at least the interacting domain of a presenilin protein to a presenilin-binding protein in the presence of a test substance, and measuring the interaction of the presenilin protein and the presenilin-binding protein. Also disclosed is method for identifying substances that modulate the nuclear translocation of an armadillo protein, including providing a culture of cells that express the armadillo protein and a mutant presenilin protein, or a functional fragment thereof that binds an armadillo protein; contacting the culture with a test substance; inducing nuclear translocation of the armadillo protein in the cells; and measuring levels of nuclear armadillo protein as compared to a control as an indication of modulatory activity of the test substance. Further disclosed is method for screening individuals for presenilin alleles associated with Alzheimer's Disease or related disorders, including obtaining cells from an individual to be tested for Alzheimer's Disease or a related disorder; inducing nuclear translocation of an armadillo protein in the cells; and measuring levels of the nuclear armadillo protein as compared to a control as an indication of the presence or absence of presenilin alleles associated with Alzheimer's Disease or a related disorder.
REFERENCES:
patent: 5449604 (1995-09-01), Schellenberg et al.
patent: 5840540 (1998-11-01), St. George-Hyslop et al.
patent: 6020143 (2000-02-01), St. George-Hyslop et al.
patent: 341 491 (1989-11-01), None
patent: WO 92/17152 (1992-10-01), None
patent: WO 95/05466 (1995-02-01), None
patent: WO 96/30499 (1996-10-01), None
patent: WO 97/03192 (1997-01-01), None
patent: WO 97/27296 (1997-07-01), None
patent: WO 98/01549 (1998-01-01), None
Levitan et al.,Nature377:354, 1995.
Levy-Lahad et al.,Science269:970-973, 1995.
Levy-Lahad et al.,Science269:973-977, 1995.
Li et al.,Proc. Natl. Acad. Sci.92:12180-12184, 1995.
Rogaev et al.,Nature376:775-778, 1995.
Schellenberg et al.,Science258:678-671, 1992.
Sherrington et al.,Nature375:754-760, 1995.
Wasco et al.,Nature Medicine1(9):848, 1995.
Zhou et al.,Neuroreport8:2085-2090, 1997.
Fraser Paul E.
St. George-hyslop Peter H.
Carlson Karen Cochrane
Fish & Neave IP Group Ropes & Gray LLP
Haley Jr. James F.
The Governing Council of the University of Toronto
LandOfFree
Alzheimer's related proteins and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Alzheimer's related proteins and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alzheimer's related proteins and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3846411