Alzheimer's disease secretase

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07812123

ABSTRACT:
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.

REFERENCES:
patent: 5424205 (1995-06-01), Dovey et al.
patent: 5455169 (1995-10-01), Mullan
patent: 5571895 (1996-11-01), Kurokawa et al.
patent: 5593846 (1997-01-01), Schenk et al.
patent: 5733768 (1998-03-01), Dixon et al.
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5750349 (1998-05-01), Suzuki et al.
patent: 5766846 (1998-06-01), Schlossmacher et al.
patent: 5795963 (1998-08-01), Mullan
patent: 5837672 (1998-11-01), Schenk et al.
patent: 5849560 (1998-12-01), Abraham
patent: 5877015 (1999-03-01), Hardy et al.
patent: 5942400 (1999-08-01), Anderson et al.
patent: 6025180 (2000-02-01), Powell et al.
patent: 6162630 (2000-12-01), Powell et al.
patent: 6211428 (2001-04-01), Singh et al.
patent: 6221645 (2001-04-01), Chrysler et al.
patent: 6245884 (2001-06-01), Hook
patent: 6245964 (2001-06-01), McLonlogue et al.
patent: 6313268 (2001-11-01), Hook
patent: 6319689 (2001-11-01), Powell et al.
patent: 6358725 (2002-03-01), Christie et al.
patent: 6361975 (2002-03-01), Christie et al.
patent: 6545127 (2003-04-01), Tang et al.
patent: 6699671 (2004-03-01), Gurney et al.
patent: 6706485 (2004-03-01), Gurney et al.
patent: 6727074 (2004-04-01), Gurney et al.
patent: 6737510 (2004-05-01), Gurney et al.
patent: 6753163 (2004-06-01), Gurney et al.
patent: 6790610 (2004-09-01), Gurney et al.
patent: 6797487 (2004-09-01), Gurney et al.
patent: 6825023 (2004-11-01), Gurney et al.
patent: 6828117 (2004-12-01), Gurney et al.
patent: 6835565 (2004-12-01), Gurney et al.
patent: 6844148 (2005-01-01), Gurney et al.
patent: 6867018 (2005-03-01), Gurney et al.
patent: 6913918 (2005-07-01), Gurney et al.
patent: 7041473 (2006-05-01), Gurney et al.
patent: 7368536 (2008-05-01), Gurney et al.
patent: 7375187 (2008-05-01), Gurney et al.
patent: 7378511 (2008-05-01), Gurney et al.
patent: 7456269 (2008-11-01), Gurney et al.
patent: 2005/0080232 (2005-04-01), Gurney et al.
patent: 0848 062 (1998-06-01), None
patent: 0855 444 (1998-07-01), None
patent: WO 96/31122 (1996-10-01), None
patent: WO 96/40885 (1996-12-01), None
patent: WO 98/13488 (1998-04-01), None
patent: WO 98/21589 (1998-05-01), None
patent: WO 98/26059 (1998-06-01), None
patent: WO 99/31236 (1999-06-01), None
patent: WO 99/34004 (1999-08-01), None
patent: WO 99/46281 (1999-09-01), None
patent: WO 99/64587 (1999-12-01), None
patent: WO 00/23576 (2000-04-01), None
patent: WO 00/47618 (2000-08-01), None
patent: WO 00/56871 (2000-09-01), None
patent: WO 00/58479 (2000-10-01), None
patent: WO 00/68266 (2000-11-01), None
patent: WO 00/69262 (2000-11-01), None
patent: WO 01/00663 (2001-01-01), None
patent: WO 01/00665 (2001-01-01), None
patent: WO 01/29563 (2001-04-01), None
patent: WO 01/31054 (2001-05-01), None
patent: WO 01/36600 (2001-05-01), None
patent: WO 01/38487 (2001-05-01), None
Vassar. Beta-secretase (BACE) as a drug target for Alzheimer's disease. Adv Drug Deliv Rev. Dec. 7, 2002;54(12):1589-602.
U.S. Appl. No. 60/141,363, filed Jun. 28, 1999, Lin et al.
U.S. Appl. No. 60/168,060, filed Nov. 30, 1999, Lin et al.
U.S. Appl. No. 60/178,368, filed Jan. 27, 2000, Lin et al.
U.S. Appl. No. 60/210,292, filed Jun. 8, 2000, Hong et al.
U.S. Appl. No. 09/277,229, filed Mar. 26, 1999, Citron et al.
U.S. Appl. No. 60/177,836, filed Jan. 25, 2000, Lin et al.
U.S. Appl. No. 60/119,571, filed Feb. 10, 1999, Basi et al.
U.S. Appl. No. 60/139,172, filed Jun. 15, 2000, Anderson et al.
U.S. Appl. No. 60/114,408, filed Dec. 13, 1998, Basi et al.
U.S. Appl. No. 09/404,578, filed Sep. 23, 1999, Chrysler et al.
U.S. Appl. No. 09/054,334, filed Apr. 2, 1998, Anderson et al.
U.S. Appl. No. 09/730,329, filed Dec. 4, 2000, Anderson et al.
U.S. Appl. No. 09/471,669, filed Dec. 24, 1999, Anderson et al.
U.S. Appl. No. 09/501,708, filed Dec. 10, 2000, Anderson et al.
U.S. Appl. No. 09/723,722, filed Nov. 28, 2000, Anderson et al.
U.S. Appl. No. 09/724,566, filed Nov. 28, 2000, Anderson et al.
U.S. Appl. No. 09/723,739, filed Nov. 28, 2000, Anderson et al.
U.S. Appl. No. 09/724,571, filed Nov. 28, 2000, Anderson et al.
U.S. Appl. No. 09/724,568, filed Nov. 28, 2000, Anderson et al.
U.S. Appl. No. 09/724,569, filed Nov. 28, 2000, Anderson et al.
Chyung et al. Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells,Journal of Cell Biology, 138: 671-680 (1997).
Evin et al., Alzheimer's disease amyloid precursor protein (AβPP): proteolytic processing, secretases and βA4 amyloid production,Amyloid; Int. J. Exp. Clin. Invest,. 1: 263-280 (1997).
Haass et al., Amyloid β-peptide is Produced by Cultured Cells During Normal Metabolism,Nature, 359: 322-325 (1992).
Haass et al., β-Amyloid Peptide and 3-kDa Fragment are Derived by Distinct Cellular Mechanisms,Journal of Biochemistry, 268: 3021-3024 (Feb. 15, 1993).
Haass et al., The Swedish Mutation Causes Early-Onset Alzheimer's Disease by β-Secretase Cleavage Within the Secretory Pathway,Nature Medicine, 12: 1291-1296 (1995).
Hirosawa et al., Characterization of cDNA Clones Selected by the GeneMark Analysis from Size-Fractionated cDNA Libraries From Human Brain,DNA Res., 6(5): 329-336 (1999).
Hussain et al., Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase,Molecular and Cellular Neuroscience, 14: 419-427 (1999).
Kang et al., The Precursor of Alzheimer's Disease Amyloid A4 Protein Resembles a Cell-Surface Receptor,Nature, 325: 733-736 (1987).
Kitaguchi et al., Novel Precursor of Alzheimer's Disease Amyloid Protein Shows Protease Inhibitory Activity,Nature, 331: 530-532 (1988).
Knops et al., Cell-type and Amyloid Precursor Protein-type Specific Inhibition of Aβ Release by Bafilomycin A1, a Selective Inhibitor of Vacuolar ATPases,Journal of Biological Chemistry, 270. 2419-2422 (1995).
Koo and Squazzo, Evidence that Production and Release of Amyloid β-Protein Involves the Endocytic Pathway,Journal of Biological Chemistry, 269: 17386-17389 (1994).
Ponte et al:, A New A4 Ainyloid mRNA Contains a Domain Homologous to Serine Proteinase Inhibitors,Nature, 331: 525-527 (1988).
Seubert et al. Secretion of β-amyloid Precursor Protein Cleaved at the Amino Terminus of the β-amyloid Peptide,Nature, 361: 260-263 (1993).
Sinha, et al., Purification and Cloning of Amyloid Precursor Protein β-Secretase from Human Brain,Nature, 402: 537-540 (1999).
Szecsi, The Aspartic Proteases,Scand. J. Clin. Lab. Invest., 52 (suppl. 210): 5-22 (1992).
Tanzi et al., Protease Inhibitor Domain Encoded by an Amyloid Protein Precursor mRNA Associated with Alzheimer's Disease,Nature, 331: 528-530 (1988).
Vasser et al., β-secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE,Science, 286 (5440): 735-41 (1999).
Yan et al., Membrane-anchored Aspartyl Protease with Alzheimer's Disease β-Secretase Activity,Nature, 402: 533-537 (1999).
Zhao et al., β-Secretase Processing of the β-Amyloid Precursor Protein in Transgenic Mice Is Efficient in Neurons but Inefficient in Astrocytes,Journal of Biological Chemistry, 271: 31407-31411 (1996).
PCT Search report for PCT/US 99/20881.
Mullan et al., A Pathogenic Mutation for Probable Alzheimer's Disease in the APP Gene at the N-Terminus of β-Amyloid Nature Genetics 1: 345-347 (1992).
Elan and Pharmacia form Alzheimer's disease research collaboration in the area of Beta-Secretase, News Aug. 9, 2000, www.elancorp.com.
Abandoned U.S. Appl. No. 09/548,369, filed Apr. 12, 2000, Turner, Methods of screening for modulators of Asp2 activity using polypeptides of SEQ ID No. 4.
Abandoned U.S. Appl. No. 09/794,748, filed Feb. 27, 2001, McGerry, Methods of using Asp2 Antisense Oligonucleotides.
Abandoned U.S. Appl. No. 10/476,935, filed Nov. 6, 2003, Wang, Asp2 polynucleotides and polypeptides.
U.S. Appl. No. 11/776,348, filed Jul. 11, 2007, Emch, Asp2 polynucleotides of SEQ I

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Alzheimer's disease secretase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alzheimer's disease secretase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alzheimer's disease secretase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4237750

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.