Alveolar surfactant proteins having cys to ser mutations

Details Alveolar surfactant proteins having cys to ser mutations Alveolar surfactant proteins having cys to ser mutations

1990-05-17

1992-04-14

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3702, C07K 710

Patent

active

051048531

ABSTRACT:
Various specific human SP-18 and human SP-5 derived peptides have alveolar surfactant protein (ASP) activity. These peptides are prepared using synthetic methods or by recombinant techniques. The peptides of the invention include surfactant proteins having serine replacements for the cysteines.

REFERENCES:
patent: 4853332 (1989-08-01), Mark et al.
Notter et al., Chem. Phys. Lipids (1987) 44(1):1-17.
Yu et al., Pediatr. Res. (1988) 23(1):23-30.
Glasser et al., J. Biol. Chem. (1988) 263(1):9-12.
Jacobs et al., J. Biol. Chem. (1987) 262(20):9808-9811.
Eistetter et al., Anticancer Res. (1987) 7(5A):909.
Weaver, Gen. Pharmacol. (1988) 19(3):361-368.
Hallman et al., J. Perinat. Med. (1987) 15(5):463-468.
Robertson, Eur. J. Respir. Dis. (1987) 71 (Supplement 153):242-248.
Johansson et al., Febs. Lett. 232(1):61-64, May 1988.
Dayoff, Atlas of Protein Sequence and Structure, vol. 5, 89-99, 1972.
Haywood, S. et al., Proc. Natl. Acad. Sci., 84:66-70, 1987.
Glasser, S. et al., Proc. Natl. Acad. Sci., 84:4007-4011, Jun. 1987.
Whitsett, J. et al., J. Biol. Chem., 260:15273-15279, 1986.
Warr, R. et al., Proc. Natl. Acad. Sci., 84:7915-7919, Nov. 1987.

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