Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1995-06-01
1998-05-26
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4242041, 4242061, 4242071, 4242081, 4242141, 4242321, 435 693, 4352351, 4351723, 4351733, 4352523, 4353201, 530350, 530826, A61K 3912, A61K 3921, C12N 1500, C07K 100
Patent
active
057561036
ABSTRACT:
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
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Audonnet Jean-Christophe Francis
Cox William I.
de Taisne Charles
Gettig Russell Robert
Johnson Gerard P.
Frommer William S.
Knode Marian C.
Kowalski Thomas J.
Salimi Ali R.
Virogenetics Corporation
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