Alternatively spliced nucleic acid molecules

Details Alternatively spliced nucleic acid molecules Alternatively spliced nucleic acid molecules

2004-10-21

2008-05-06

Landsman, Robert (Department: 1647)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S252300, C435S320100, C435S325000, C435S471000

Reexamination Certificate

active

07368553

ABSTRACT:
The invention provides an isolated or purified nucleic acid molecule comprising SEQ ID NO:1, which contains cDNA comprising exons 1-5 of a vascular endothelial growth factor (VEGF) joined to genomic DNA comprising introns 5, 6, and 7 and exons 6, 7, and 8 of VEGF and a mutation in one or more of the splice donor, branch point, and splice acceptor regions, which promotes the production of a VEGF189isoform. Expression constructs, compositions, and cells comprising such a nucleic acid molecule also are provided by the invention.

REFERENCES:
patent: WO 94/01548 (1994-01-01), None
Amano et al., “Alteration of splicing signals in a genomic/cDNA hybrid VEGF gene to modify the ratio of expressed VEGF isoforms enhances safety of angiogenic gene therapy,”Mol. Ther., 12 (4), 716-724 (Oct. 2005).
Whitlock et al., “Adenovirus-mediated transfer of a minigene expressing multiple isoforms of VEGF is more effective at inducing angiogenesis than comparable vectors expressing individual VEGF cDNAs,”Mol. Ther., 9 (1), 67-75 (Jan. 2004).
Williams, Database GenEmbl on LOCUS, Accession No. AL136131, “Direct Submission,” Gene Sequence (Dec. 12, 2000).

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