Alternative oxidase and uses thereof

Details Alternative oxidase and uses thereof Alternative oxidase and uses thereof

2006-11-01

2009-08-11

Pak, Yong D (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S004000, C435S006120, C435S069100, C435S071100, C435S025000, C435S252300, C435S320100, C435S440000, C435S325000, C536S023200, C536S023400

Reexamination Certificate

active

07572616

ABSTRACT:
The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX in human cells and inDrosophilahas been shown to confer spectacular cyanide-resistance to mitochondrial substrate oxidation, alleviate oxidative stress, apoptosis susceptibility and metabolic acidosis. AOX is well tolerated when expressed ubiquitously in the whole organism. AOX expression is a valuable tool to limit the deleterious consequences of respiratory chain deficiency.

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