Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 24 amino acid residues in defined sequence
Patent
1996-02-09
1998-11-24
LeGuyader, John L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
24 amino acid residues in defined sequence
530328, C07K 706, C07K 1447
Patent
active
058408398
ABSTRACT:
The present invention discloses that the normal melanogenic gene, gp75 gene, encodes a gene product, a 24 amino acid peptide of ORF3, which is processed to an antigenic cancer peptide recognized by T lymphocytes. The cancer peptide of the invention derived from ORF3 is recognized by cancer antigen specific T lymphocytes as a tumor rejection antigen. The products of this gene are promising candidates for immunotherapeutic strategies for the treatment and diagnosis of patients with cancer.
REFERENCES:
Kawakami, Y. et al, Identification of the Immunodominant Peptides of the MART-1 Human Melanoma Antigen Recognized by the Majority of HLA-A2-restricted Tumor Infiltrating Lymphocytes, The Journal of Experimental Medicine, vol. 180, pp. 347-352, Jul. 1994.
Yokoyama et al, Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyroinase-related protein-2, Biochimica et Biophysica Acta, 1217 (1994) 317-321.
Bloom et al, Identification of Tyrosinase-related Protein 2 as a Tumor Rejection Antigen for the B16 Melanoma, The Journal of Experimental Medicine, vol. 185, No. 3, pp. 453-459, Feb. 3, 1997.
Wang et al, Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes, The Journal of Experimental Medicine, 184, pp. 2207-2216 Dec. 1996.
Orlow et al, Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression, Proc. Natl. Acad. Sci. USA, vol. 92, pp. 10152-10156, Oct. 1995.
Vijayasaradhi et al, The Melanoma Antigen gp75 Is The Human Homologue Of The Mouse b (Brown) Locus Gene Product, J. Exp. Med., vol. 171, Apr. 1990, pp. 1375-1380.
Cohen et al, Nucleotide sequence of the cDNA encoding human tyrosinase-related protein, Nucleic Acids Research, vol. 18, No. 9, May 11, 1990, pp. 2807-2808.
Hara et al, Implicating a Role for Immune Recognition of Self in Tumor Rejection Passive Immunization against the Brown Locus Protein, J. Exp. Med., vol. 182, Nov. 1995, pp. 1609-1614.
Quelle et al, Alternative Reading Frames of the INK4a Tumor Suppressor Gene Encode Two Unrelated Proteins Capable of Inducing Cell Cycle Arrest, Cell, vol. 83, Dec. 15, 1995, pp. 993-1000.
Malarkannan et al, A Rare Cryptic Translation Product is Presented by K.sup.b Major Histocompatibility Complex Class I Molecule to Alloreactive T Cells, J. Exp. Med., vol. 182, Dec. 1995, pp. 1739-1750.
Wang et al, Identification of a Gene Encoding a Melanoma Tumor Antigen Recognized by HLA-A31-restricted Tumor-infiltrating Lymphocytes, The Journal of Experimental Medicine, vol. 181, Feb. 1995, pp. 799-804.
Wang et al, Human tumor antigens recognized by T lymphocytes: implications for cancer therapy J. Leukocyte Biol., vol. 60, pp. 296-309, Sep. 1990.
Uenaka et al, Identification of a Unique Antigen Peptide pRL1 on BALB/c RL01 Leukemia Recognized by Cytotoxic T Lymphocytes and Its Relation to the Akt Oncogene J. Exp. Med., vol. 180, pp. 1599-1607, Nov. 1994.
Rosenberg Steven A.
Wang Rong-Fu
LeGuyader John L.
Schwartzman Robert
The United States of America as represented by the Secretary of
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