Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Nucleoproteins – e.g. – chromatin – chromosomal proteins,...
Patent
1998-02-04
1999-06-29
McKelvey, Terry
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Nucleoproteins, e.g., chromatin, chromosomal proteins,...
530350, C07K 1447
Patent
active
059170190
ABSTRACT:
The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
REFERENCES:
patent: 5733730 (1998-03-01), de Lange
Bilaud et al, 1996, Nucl Acids Res, 24:1294-303.
Conrad et al, 1990, Cell, 63:739-50.
Gilson et al, J Mol Biol, 1995, 231:293-310.
Hanish et al, 1994, Proc Natl Acad Sci USA, 91:8861-5.
Harley et al, 1992, Exp Gerontol, 27:375-82.
Hovring et al, 1994, J Biol Med, 296:17663-9.
Krauskopf et al, 1996, Nature, 383-354-7.
Kyrion et al, 1992, Mol Cell Biol, 12:5159-73.
Li et al, 1996, Gen Dev, 10:1310-26.
Lundblad et al, 1996, Cell, 87:369-75.
Lustig et al, 1990, Science, 250:549-53.
McEachern et al, 1995, Nature, 376:403-9.
Metcalfe et al, 1996, Nature Gen, 13:350-3.
Muller et al, 1994, J Struct Biol, 113:1-12.
Saukumar et al, 1994, Oncogene, 9:1279-87.
Sandell et al, 1993, Cell, 75:729-41.
Shore et al, 1994, Trends Gen, 10:408-12.
Singer et al, 1994, Science, 266:404-9.
Smith et al, 1997, Trends Gen, 13:21-6.
Vignais et al, 1989, J Biol Chem, 264:8463-6.
Yu et al, 1990, Nature, 344:126-132.
Zakian, 1995a, Sacharomyces telomers: function, structure and replication, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp. 107-138.
Zhong et al, 1992, Mol Cell Biol, 13:4834-43.
Chong et al, 1995, Science, 270:1663-7.
Blasco et al, Cell, 1996, 91:25-34.
Zakain et al, Cell, 1996, 91:1-3.
Pandita et al, Cytogenet Cell Genet, 1995, 71:86-93.
Sprung et al, Nature, 1995, 379:177-84.
Bodner et al, 1998, Science, 279:349-52.
van Steensel et al, 1998, Cell, 92:401-13.
van Steensel and de Lange, 1997, Nature, 385:740-3.
Bianchi Alessandro
De Lange Titia
Steensel Bas Van
McKelvey Terry
The Rockefeller University
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