Altered polypeptides with increased half-life

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

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4241531, 4351721, 5303873, 53038815, 5303887, 5303911, A61K 39395, C12N 1513, C12P 2108, C07K 1628

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active

058690468

ABSTRACT:
Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life.

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