Altered polypeptides with increased half-life

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

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530300, 530350, 5303871, C07K 708, C07K 1447, C07K 1600, C07K 1646

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active

057392773

ABSTRACT:
Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life.

REFERENCES:
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