Altered peptide ligands of GAD65

Details Altered peptide ligands of GAD65 Altered peptide ligands of GAD65

2011-08-09

2011-08-09

Ewoldt, Gerald R (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C424S185100

Reexamination Certificate

active

07994279

ABSTRACT:
Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-risk of Type 1 diabetes.

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