Altered major histocompatibility complex (MHC) determinant and m

Details Altered major histocompatibility complex (MHC) determinant and m Altered major histocompatibility complex (MHC) determinant and m

1995-06-07

1999-11-02

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241931, 530350, 530402, 530403, 435 697, 514 12, 514 13, 514 14, A61K 39385, C07K 1674

Patent

active

059765518

ABSTRACT:
An altered MHC class II determinant comprises .alpha..sub.1, .alpha..sub.2, .beta..sub.1, .beta..sub.2, domains of a mammalian MHC class II locus in which the domains are covalently linked to form a construct comprising the .beta..sub.2 -.alpha..sub.2 -.alpha..sub.1 .beta..sub.1 domains in sequence. The altered class II determinants can be associated with an antigen to elicit an immune response. In addition, the altered determinants may be used to prepare antibodies. The antibodies so produced have various diagnostic and therapeutic uses.

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