Altered major histocompatibility complex (MHC) determinant and m

Details Altered major histocompatibility complex (MHC) determinant and m Altered major histocompatibility complex (MHC) determinant and m

1995-06-07

2000-01-04

Cunningham, Thomas M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4241921, 530350, 455325, 455243, 455455, 455 691, C07H 2104, C12N 1585, C12N 120, C12N 1563

Patent

active

060111461

ABSTRACT:
An altered MHC class I determinant comprises .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .beta..sub.2 -microglobulin (.beta..sub.2 m) polypeptide domains encoded by a mammalian MHC class I locus in which the .alpha..sub.3 domain is covalently linked to the .beta..sub.2 M domain. An altered MHC class II determinant comprises .alpha..sub.1, .alpha..sub.2, .beta..sub.1, and .beta..sub.2 polypeptide domains encoded by a mammalian MHC class II locus, in which the domains are covalently linked to form a polypeptide comprising the .beta..sub.2 -.alpha..sub.2 -.alpha..sub.1 -.beta..sub.1 domains in sequence. The altered MHC class I and class II determinants can be associated with an antigen to elicit an immune response. The invention can be used in the immunization or treatment of diseases such as AIDS, multiple sclerosis, lupus erythematosus, toxic shock or snake bite.

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