Altered insulin-like growth factor binding proteins

Details Altered insulin-like growth factor binding proteins Altered insulin-like growth factor binding proteins

2003-07-11

2009-02-10

Kemmerer, Elizabeth C. (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C536S023100

Reexamination Certificate

active

07488798

ABSTRACT:
Altered IGFBPs are able to bind IGF, but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and to two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by use of the altered IGFBPs.

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