Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-09-06
2005-09-06
Wax, Robert A. (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C424S094100
Reexamination Certificate
active
06939850
ABSTRACT:
Described herein is the discovery that human interleukin-1β convertase (ICE) is structurally similar to the protein encoded by theC. eleganscell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 protein may be a cysteine protease like ICE and that ICE may be a human equivalent of the nematode cell death gene. Another mammalian protein, the murine NEDD-2 protein, was also found to be similar to Ced-3. The NEDD-2 gene is implicated in the development of the murine central nervous system. On the basis of these findings, novel drugs for enhancing or inhibiting the activity of ICE, ced-3, or related genes are provided. Such drugs may be useful for treating inflammatory diseases and/or diseases characterized by cell deaths, as well as cancers, autoimmune disorders, infections, and hair growth and hair loss. Furthermore, such drugs may be useful for controlling pests, parasites and genetically engineered organisms. Furthermore, novel inhibitors of the activity of ced-3, ICE and related genes are described which comprise portions of the genes or their encoded products.
REFERENCES:
patent: 5278061 (1994-01-01), Bull et al.
patent: 5416013 (1995-05-01), Black et al.
patent: 5492824 (1996-02-01), Talanian et al.
patent: A 053 3350 (1993-03-01), None
patent: WOA 911 5577 (1991-10-01), None
patent: WO 91/19007 (1991-12-01), None
patent: WOA 920 7071 (1992-04-01), None
Black et al., “Activation of interleukin-1β by a co-induced protease”, FEBS Letters 247(2):386-390 (1989).
Black et al., “A Pre-aspartate-specific Protease from Human Leukocytes that Cleave Pro-interleukin-1β”, J. Biol. Chem. 264(10):5323-5326 (1989).
Brenneman et al., “Cytokine Regulation of Neuronal Survival”, J. Neurochem. 58(2):454-460 (1992).
Cerretti et al., “Molecular Cloning of the Interleukin-1β Converting Enzyme”, Science 256:97-100 (1992).
Colotta et al., “Modulation of Granulocyte Survival and Programmed Cell Death by Cytokines and Bacterial Products”, Blood 80(8):2012-2020 (1992).
Estrov et al., “Suppression of Chronic Myelogenous Leukemia Colony Growth by Interleukin-1 (IL-1) Receptor Antagonist and Soluble IL-1 Recept.: A Novel Application for Inhibitors of IL-1 Activity”, Blood 78(6):1476-1484 (1991).
Fuhlbrigge et al., “Molecular Biology and Genetics of Interleukin-1”, Year Immunol. 5:21-37 (1989).
Hogquist et al., “Interleukin 1 is Processed and Released During Apoptosis”, Proc. Natl. Acad. Sci. USA 88:8485-8489 (1991).
Horvitz and Chalfie, “Implications of Nematode Neuronal Cell Death for Human Neurological Disorders” in Neurodegenerative Disorders: Mechanisms and Prospects for Therapy, Price et al., (eds.) John Wiley & Sons, (1991) pp. 5-19.
Jacobson et al., “Breaking the ICE” Current Biology 4(4):337, 1994.
Kostura et al., “Identification of a monocyte specific pre-interleukin 1β convertase activity”, Proc. Natl. Acad. Sci. USA 86:5227-5231 (1989).
Kronheim et al., “Purification of Interleukin-1β Converting Enzyme, the Protease that Cleaves the Interleukin-1β Precursor”, Archives of Biochemistry and Biophysics 296:698-703 (1992).
Kumar et al., “Identification of a Set of Genes with Developmentally Down-Regulated Expression in the Mouse Brain”, Biochem. Biophys. Res. Comm. 185(3):1155-1161 (1992).
Ledoux et al., “Isolation of nematode homologs of theC. eleganscell death gene ced-3” Neurobiology of Aging 13:S47 (1992).
Lotem and Sachs, “Hematopoietic Cytokines Inhibit Apoptosis Induced by Transforming Growth Factor β1 and Cancer Chemotherapy Compounds in Myeloid Leukemic Cells”, Blood 80(7):1750-1757 (1992).
Mangan and Wahl, “Differential Regulation of Human Monocyte Programmed Cell Death (Apoptosis) by Chemotactic Factors and Pro-Inflammatory Cytokines”, J. Immun. 147(10):3408-3412 (1991).
Mangan et al., “IL-4 Enhances Programmed Cell Death (Apoptosis) in Stimulated Human Monocytes”, J. Immun. 148(6):1812-1816 (1992).
Mangan et al., “Lipopolysaccharide, Tumor Necrosis Factor-a and IL-1β Prevent Programmed Cell Death (Apoptosis) in Human Peripheral Blood Monocytes”, J. Immun. 146:1541-1546 (1991).
McConkey et al., “Agents that Elevate cAMP Stimulate DNA Fragmentation in Thymocytes”, J. Immun. 145(4):1227-1230 (1990).
McConkey et al., “Interleukin 1 Inhibits T Cell Receptor-Mediated Apoptosis in Immature Thymocytes”, J. Biol. Chem. 265(6):3009-3011 (1990).
(Merck & Co. Inc.) Database WPI Week 9318 AN 93-144400 Feb. 1993 Abstract, Derwent Publications Ltd. London, GB.
Miller et al., “The IL-1β Converting Enzyme as a Therapeutic Target” Ann. NY Acad. Sci. 696:133, 1993.
Miura et al., “Induction of Apoptosis in Fibroblasts by IL-1β-Converting Enzyme, a Mammalian Homolog of theC. elegansCell Death Gene ced-3” Cell 75:653, 1993.
Molineaux et al., “Interleukin 1β (IL-1β) processing in murine macrophages requires a structurally conserved homologue of human IL-1β”, Proc. Natl. Acad. Sci. USA 90:1809-1813 (1993).
Nett et al., “Molecular Cloning of the Murine IL-1β Converting Enzyme cDNA”, J. Immun. 149:3254-3259 (1992).
Pickup et al., “Hemmorrhage in Lesions Caused by Cowpox Virus is Induced by a Viral Protein that is Related to Plasma Protein Inhibitors of Serine Proteases”, Proc. Natl. Acad. Sci. USA 83:7698-7702 (1986).
Rambaldi et al., “Modulation of Cell Proliferation and Cytokine Production in Acute Myeloblastic Leukemia by Interleukin-1 Receptor Antagonist and Lack of its Expression by Leukemic Cells”, Blood 78(12):3248-3253 (1991).
Ray et al., “Viral Inhibition of Inflammation: Cowpox Virus Encodes an Inhibitor of the Interleukin-1β Converting Enzyme”, Cell 69:597-604 (1992).
Sleath et al., “Substrate Specificity of the Protease that Processes Human Interleukin-1β”, J. Biol. Chem. 265(24):14526-14528 (1990).
Thornberry et al., “A Novel Heterodimeric Cysteine Protease is required for Interleukin-1β Processing in Monocytes”, Nature 356:768-774 (1992).
Wang et al., “ich-d1, and Ice/ced-3-Related Gene, Encodes Both Positive and Negative Regulators of Programmed Cell Death” Cell 78:739, 1994.
Yuan, J., Dissertation Abstracts International, vol. 50/10-B, (1989).
Horvitz H. Robert
Shaham Shai
Yuan Junying
Bieker-Brady Kristina
Clark & Elbing LLP
Massachusetts Institute of Technology
Mayer Suzanne M.
Wax Robert A.
LandOfFree
Altered human interleukin-1β convertase (ICE), NEDD-2,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Altered human interleukin-1β convertase (ICE), NEDD-2,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Altered human interleukin-1β convertase (ICE), NEDD-2,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3380344