Alteration of sequence of a target molecule by ribozyme catalyze

Details Alteration of sequence of a target molecule by ribozyme catalyze Alteration of sequence of a target molecule by ribozyme catalyze

1997-01-24

1999-02-09

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 912, 536 245, 536 231, 536 243, 536 2431, 514 44, C12Q 168, C07H 2102, C07H 2104, A61K 4800

Patent

active

058692541

ABSTRACT:
Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that protein naturally produced from the target nucleic acid prior to splicing. The method includes contacting the target nucleic acid molecule with a catalytic nucleic acid molecule including the separate nucleic acid molecule. Such contacting is performed under conditions in which at least a portion of the separate nucleic acid molecule is spliced with at least a portion of the target nucleic acid molecule to form a chimeric nucleic acid molecule. In this method, the catalytic nucleic molecule is chosen so that it is not naturally associated with the separate nucleic acid molecule.

REFERENCES:
patent: 5498531 (1996-03-01), Jarrell
patent: 5641673 (1997-06-01), Haseloff et al.
patent: 5667969 (1997-09-01), Sullenger et al.
Rossi, "Controlled, targeted, intracellular expression of ribozymes: progress and problems", Trends in Biotechnology 13(8):301-305, Aug. 1995.
Weber et al, "Antiviral properties of a dominant negative mutant of theherpessimplex virus type 1 regulatory protein (ICPO)", J. Gen. Virol. 73:2955-2961, 1992.

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