Alteration of sequence of a target molecule by ribozyme catalyze

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 5, 435 912, 536 245, 536 231, 536 243, 536 2431, 514 44, C12Q 168, C07H 2102, C07H 2104, A61K 4800

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058692541

ABSTRACT:
Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that protein naturally produced from the target nucleic acid prior to splicing. The method includes contacting the target nucleic acid molecule with a catalytic nucleic acid molecule including the separate nucleic acid molecule. Such contacting is performed under conditions in which at least a portion of the separate nucleic acid molecule is spliced with at least a portion of the target nucleic acid molecule to form a chimeric nucleic acid molecule. In this method, the catalytic nucleic molecule is chosen so that it is not naturally associated with the separate nucleic acid molecule.

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patent: 5667969 (1997-09-01), Sullenger et al.
Rossi, "Controlled, targeted, intracellular expression of ribozymes: progress and problems", Trends in Biotechnology 13(8):301-305, Aug. 1995.
Weber et al, "Antiviral properties of a dominant negative mutant of theherpessimplex virus type 1 regulatory protein (ICPO)", J. Gen. Virol. 73:2955-2961, 1992.

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