Alteration of pharmacokinetics of proteins by charge modificatio

Details Alteration of pharmacokinetics of proteins by charge modificatio Alteration of pharmacokinetics of proteins by charge modificatio

1995-09-26

1997-06-03

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated to proteinaceous toxin or fragment thereof

4241781, 5303911, 5303917, 530402, 530410, A61K 39395, C07K 1600

Patent

active

056351801

ABSTRACT:
There is disclosed charge-modified conjugates comprising a targeting protein bound to a therapeutic or diagnostic agent. Charge-modifying a conjugate to cause an acidic shift in the isoelectric point results in prolonged serum half-life upon in vivo administration and is useful to accumulate a therapeutic agent at the target site. Conversely, charge-modification to cause a basic shift in the isoelectric point of the conjugate reduces serum half-life upon in vivo use for diagnostic imaging purposes and results in higher target-to-background ratios.

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