Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1994-09-14
1998-04-07
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241841, 4241931, 530300, 530327, 530332, 530868, 514 2, 514 15, A61K 3800, C07K 702, C07K 704
Patent
active
057361428
ABSTRACT:
The present invention provides compositions and methods of inhibiting or inducing activation of T cells in a patient. The methods comprise administering a therapeutically effective dose of pharmaceutical compositions comprising a pharmaceutically acceptable carrier and peptides of between about 4 and about 20 residues, that bind antigen binding sites on MHC molecules encoded by substantially all alleles of a DR locus. These peptides are referred to as pan DR binding peptides. The pan DR binding peptides can be used to inhibit immune responses associated with immunopathologies, such as autoimmunity, allograft rejection and allergic responses. The peptides can also be used in combination with CTL peptides to enhance a CTL response.
REFERENCES:
Brown, Jerry H., et al. (1993) "Three-dimensional structure of the human class II histocompatibility antigen HLS-DR1", Nature 364:33-39.
Krieger, Jeffrey I., et al. (1991) "Single Amino Acid Changes in DR and Antigen Define Residues Critical For Peptide-MHC and T Cell Recognition", Journal of Immunology, 146:2331-2340.
O'Sullivan, Deirdre, et al. (1991) "Truncation Analysis of Several DR Binding Epitopes", The Journal of Immunology, 146:1240-1246.
O'Sullivan, Deirdre, et al. (1991) "On the Interaction of Promiscuous Antigenic Peptides With Different DR Alleles", The Journal of Immunology, 147: 2663-2669.
Busch, Robert, et al. (1990) "Degenerate binding of Immunogenic peptides to HLA-DR proteins on B cell surfaces", International Immunology, 2:443-451.
Panina-Bordignon, Paola, et al. (1989) "Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells", Eur. J. Immunol., 19:2237-2242.
Sinigaglia, F., et al. (1988) "A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules", Nature, 336:778-780.
Roche, Paul, et al. (1990) "High-Affinity Binding of an Influenza Hemagglutinin-Derived Peptide to Purified HLS-DR", The Journal of Immunology, 144:1849-1856.
Hill, Mark C., et al. (1991) "Conformational and Structural Characteristics of Peptides Binding to HLA-DR Molecules", The Journal of Immunol. 147:189-197.
Alexander Jeffrey L.
Gaeta Federico
Grey Howard M.
Sette Alessandro
Sidney John
Cunningham Thomas M.
Cytel Corporation
LandOfFree
Alteration of immune response using pan DR-binding peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Alteration of immune response using pan DR-binding peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alteration of immune response using pan DR-binding peptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-10386