Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2006-03-16
2008-09-16
Campell, Bruce (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S325000, C435S091420
Reexamination Certificate
active
07425337
ABSTRACT:
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication competent alphavirus particles, as determined by passage on cells in culture. The compositions include helper and replicon nucleic acid molecules that can further reduce the predicted frequency for formation of replication-competent virus and can optimize manufacturing strategies and costs.
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Caley Ian J.
Dryga Sergey A.
Kamrud Kurt I.
Rayner Jonathan O.
Smith Jonathan F.
AlphaVax, Inc.
Blumel Benjamin P
Myers Bigel Sibley & Sajovec P.A.
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