Alpha1a adrenergic receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514307, 514318, 514321, 514322, 514323, 514324, 514326, 514367, 514372, 514373, 514375, 514378, 514379, 514394, 514406, 546139, 546167, 546193, 546194, 546196, 546197, 546198, 546199, 546201, 546202, 546205, 546211, 548152, 548159, 548206, 548207, 548217, 548241, 548247, 5483061, 5483611, 5483641, 5483644, 5483657, A61K 3147, A61K 31415, A61K 3142, A61K 31425, A61K 31445, C07D40104, C07D40904

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active

056681488

ABSTRACT:
Compounds that specifically bind to the human alpha1a adrenergic receptor, including compounds effective to reduce symptoms of benign prostatic hypertrophy include compounds of formula: ##STR1## wherein: Ar1 and Ar2 can be independantly aromatic, heteroaromatic, or condensed heteroaromatic unsubstituted or substituted with amino, alkoxy, sulfonamido, alkyl, heteroalkyl, halo;

REFERENCES:
patent: 5403847 (1995-04-01), Gluchowski et al.
Metcalf BW, Levy MA, Holt DA, TIPS 10, pp. 490-495. Dec. 1989.

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