Alpha tocopherol-based vesicles

Details Alpha tocopherol-based vesicles Alpha tocopherol-based vesicles

1988-12-06

1991-08-20

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

264 41, 264 46, 424 71, 424450, 4284022, 436829, 514458, 514885, 514913, A61K 9139, A61K 9133, A61K 31355, A61K 4300

Patent

active

050412787

ABSTRACT:
Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.

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