Alpha-synuclein kinase

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S320100, C435S252300, C536S023100, C530S350000

Reexamination Certificate

active

07553639

ABSTRACT:
The invention provides agents and methods for treatment of diseases associated with Lewy body diseases (LBDs) in the brain of a patient. Preferred agents include inhibitors of PLK2 and GRK6 kinases.

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Inglis et al. Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in the central nervous system. J. Biol. Chem. Papers in Press, Published Nov. 12, 2008.
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