.alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-d

Details .alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-d .alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-d

1984-08-10

1986-07-01

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548348, A61K 31415, C07D40304, C07D40514

Patent

active

045980861

ABSTRACT:
Indole derivatives, in the form of racemates or optically active isomers, of the formula (I) ##STR1## in which R.sub.1 is a hydrogen atom, a linear or branched (C.sub.1-6) alkyl group, a (C.sub.3-6) cycloalkyl-(C.sub.1-4) alkyl group, a (C.sub.2-6) alkenyl group, the naphthylmethyl group, the phenethyl group or a benzyl group optionally substituted by one or more halogen atom or methyl, methoxyl or methylenedioxy group and R.sub.2 is H or a (C.sub.1-4) alkyl or allyl group, and their pharmaceutically acceptable salts; are .alpha..sub.2 -antagonists and useful for the treatment of depression, hypotension, post-operative paralytic ileum, asthma and obesity.

REFERENCES:
patent: 4280327 (1980-06-01), Yonan
patent: 4315019 (1982-02-01), Malen et al.
patent: 4328234 (1982-05-01), Thorogood
patent: 4378357 (1983-03-01), Miller et al.
patent: 4391814 (1983-07-01), Vorbruggen
patent: 4411908 (1983-10-01), Chapleo et al.
Burger, "Rational Approaches to Drug Structure", J. Chem. Ed., 33, No. 8., p. 362-372, 1956.
Morrison and Boyd, "Organic Chemistry", 4th Ed., 1983, p. 902.
Barton, "Protection of N-H Bonds and NR.sub.3 ", Protective Groups in Organic Chemistry, (Ed. Mcomie, 1976), pp. 62-63.

Affiliated with

Also associated with

Rating

.alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1082755