.alpha..sub.2 -Adrenoceptor antagonistic benzoquinolizines

Details .alpha..sub.2 -Adrenoceptor antagonistic benzoquinolizines .alpha..sub.2 -Adrenoceptor antagonistic benzoquinolizines

1983-03-03

1984-11-06

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424258, 544126, 546 95, A61K 31535, C07D45506

Patent

active

044812000

ABSTRACT:
The invention concerns benzoquinolizines of formula ##STR1## and their pharmaceutically acceptable acid addition salts. In the formula R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy or halogen, R.sup.3 represents methyl or ethyl, A represents a direct bond between the S and N atoms or a lower alkylene group having 1 to 3 carbon atoms in the chain between the S and N atoms, R.sup.4 and R.sup.5 each independently represent hydrogen, lower alkyl, aryl or aryl(lower)alkyl or together with the nitrogen atom to which they are attached represent a five or six membered heterocyclic ring. The compounds possess .alpha..sub.2 -adrenoceptor antagonistic activity and can be incorporated into pharmaceutical compositions.

REFERENCES:
patent: 4183937 (1980-01-01), Ward
Hamilton, C. et al., in Frontiers in Hypertension Research (Laragh et al., editors), Springer-Verlag, New York, 1981, pp. 348-352.

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