.alpha..sub.2 -Adrenoceptor antagonistic benzoquinolizines

Details .alpha..sub.2 -Adrenoceptor antagonistic benzoquinolizines .alpha..sub.2 -Adrenoceptor antagonistic benzoquinolizines

1982-09-09

1984-06-12

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 95, A61K 3147, C07D45506

Patent

active

044541392

ABSTRACT:
The invention concerns benzoquinolizines of formula ##STR1## and their acid addition salts. In the formula R.sup.7 is lower alkyl or a phenyl or naphthyl radical optionally substituted with specified substituents and R.sup.8 is methyl or ethyl. The compounds possess high .alpha..sub.2 (presynaptic) adrenoceptor antagonistic activity and a good .alpha..sub.2 /.alpha..sub.1 antagonistic selectivity.

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