Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and r

Details Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and r Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and r

1991-09-26

1992-12-22

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548429, A61K 3140, C07D20958

Patent

active

051734974

ABSTRACT:
This invention relates to compounds of the formula ##STR1## where X is --NH, oxygen, N-loweralkyl, or N-arylloweralkyl; R.sub.1 is hydrogen, loweralkyl, cycloalkyl, aryl, arylloweralkyl, loweralkylene, haloloweralkyl, heteroaryl selected from the group consisting of thienyl, furnayl, pyrrolyl and pyridinyl; heteroarylloweralkyl, heterocyclic selected from piperidinyl, piperazinyl, pyrrolidinyl; or heterocyclicloweralkyl; R.sub.2 is hydrogen or loweralkyl; R.sub.3 is loweralkyl or arylloweralkyl; R.sub.4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl; Y is hydrogen, loweralkyl or loweralkoxy, and the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention are useful in the treatment of memory impairment characterized by a cholinergic deficit such as that associated with electroshock-induced amnesia and Alzheimer's disease and other senile dementia.

REFERENCES:
patent: 5077289 (1991-12-01), Glamkowski et al.
Hawley's Consensed Chemical Dictionary, Van Nostrand Runhold 1987, p. 100.

Affiliated with

Also associated with

Rating

Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and r does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and r, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and r will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-975507