.alpha.-N-Acetyl-L-phenylalanyl-L-arginine ethyl ester

Details .alpha.-N-Acetyl-L-phenylalanyl-L-arginine ethyl ester .alpha.-N-Acetyl-L-phenylalanyl-L-arginine ethyl ester

1979-03-08

1980-11-18

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435 24, C07C10352, C12Q 136

Patent

active

042344778

ABSTRACT:
The new compound acetylphenylalanyl-arginine ethyl ester (Ac-Phe-Arg OEt) and its acid addition salts are used in the diagnostic determination of the content of Kallikrein. In view of the role of Kallikrein in regulating blood pressure or the renal function, the reliable determination of small amounts of Kallikrein such as occur in urine, saliva or glands is important but has been difficult to achieve. Ac-Phe-Arg OEt and its esters provide a substrate for use in such determinations and allow a significant improvement in accuracy.

REFERENCES:
Pettit, "Synthetic Peptides," vol. 3, (1978).
T. Morita, "Computer Print Out Mid-Line," J. Biochem. (Tokyo) 85 (2) 1495-1498, 1977.

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