Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1993-06-08
1995-01-03
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544123, C07D41304, C07D47302, C07D47326
Patent
active
053788419
ABSTRACT:
Alpha-morpholino subunits and polymer compositions composed of alpha-morpholino subunits are disclosed. These subunits can be linked together by uncharged linkages, one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide. The polymers of the instant invention can be used in place of standard RNA or DNA oligomers. For example, the target-specific polymers of the invention can be used in a variety of diagnostic assays for detection of RNA or DNA having a given target sequence. Further, the polymers of the invention also have potential use as therapeutic agents.
REFERENCES:
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5142047 (1992-08-01), Summerton et al.
patent: 5185444 (1993-02-01), Summerton et al.
patent: 5217866 (1993-06-01), Summerton et al.
Uchiyama et al., Chemical Abstract 112:139741s (1990), Abstract for JP 01, 172,384 (Jul. 7, 1989).
Stirchak, Nucleic Acids Research, vol. 17, No. 15 (1989), pp. 6129-6141.
Stirchak Eugene P.
Summerton James E.
Weller Dwight D.
Antivirals Inc.
Datlow Philip I.
Dehlinger Peter J.
Fabian Gary R.
Shah Mukund J.
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