.alpha.-methylenecyclopentanone derivative and process for produ

Details .alpha.-methylenecyclopentanone derivative and process for produ .alpha.-methylenecyclopentanone derivative and process for produ

1992-02-12

1995-01-10

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

556413, 556415, 556423, 556428, 556437, 568325, 568329, 568330, 568 42, 568 55, 568 57, 549416, 549422, 564374, 564462, 558388, 560 53, 560121, 560126, C07F 708, C07F 710, C07F 718

Patent

active

053809009

ABSTRACT:
Disclosed herein is an .alpha.-methylene-cyclopentanone derivative represented by the formula [I] below which is useful as an intermediate for pharmaceuticals and insecticides, especially prostaglandins. Also disclosed herein is a process for producing the derivative advantageously on an industrial scale. ##STR1## where X denotes (.alpha.-OZ, .beta.-H) or (.alpha.-H, .beta.-OZ), with Z representing a protecting group for the hydroxyl group; U denotes (.alpha.-H, .beta.-R.sup.1) or (.beta.-R.sup.1, .alpha.-H); R.sup.1 denotes ##STR2## where R.sup.2 denotes a protected hydroxyl group, a substituted or unsubstituted C.sub.1-15 alkyl group, a substituted or unsubstituted C.sub.2-15 alkenyl group, a substituted or unsubstituted C.sub.2-15 alkynyl group, or a substituted or unsubstituted C.sub.6-15 aryl group; Z' denotes a protecting group for the hydroxyl group; and k is 0 or 1).

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