Alpha-mercaptomethyl-benzene propanamides, pharmaceutical compos

Details Alpha-mercaptomethyl-benzene propanamides, pharmaceutical compos Alpha-mercaptomethyl-benzene propanamides, pharmaceutical compos

1988-02-23

1989-06-13

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 5142275, 514255, 540606, 544 581, 544159, 544382, 546224, 548557, A61K 3140, A61K 31535, C07D29522

Patent

active

048393584

ABSTRACT:
Novel .alpha.-mercaptomethyl-benzene propanamides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and ##STR2## R.sub.1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of --OH, --NO.sub.2, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, X and X' are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 5 carbon atoms, --OH, halogen and --CF.sub.3, R.sub.2 is selected from the group consisting of pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, tetrahydrothiazinyl and hexahydroazepinyl, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, --NO.sub.2, --CF.sub.3, halogen and acyl of an organic carboxylic acid of 1 to 7 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic activity, antidepression and anxiolytic properties.

REFERENCES:
patent: 4216160 (1980-08-01), Dorn et al.
patent: 4263293 (1981-04-01), Sundeen et al.

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