Alpha-mercaptoacrylic acid derivatives having calpain inhibitory

Details Alpha-mercaptoacrylic acid derivatives having calpain inhibitory Alpha-mercaptoacrylic acid derivatives having calpain inhibitory

1993-05-21

1996-09-10

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40306, C07D20930, C07D20918, A61K 3141

Patent

active

055547672

ABSTRACT:
The invention covers a novel series of .alpha.-mercaptoacrylic acid derivatives that inhibit both calpain I and calpain II with a high affinity and selectivity. The compounds are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders, brain injury, spinal cord, and peripheral nerve injury, cardiac infarction, cataracts, inflammation, restenosis, muscular dystrophy, and platelet aggregation. Pharmaceutical compositions, methods of using processes for preparing and novel intermediates useful in the processes are also disclosed.

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