Alpha-mannosidase and fucosidase inhibitors

Details Alpha-mannosidase and fucosidase inhibitors Alpha-mannosidase and fucosidase inhibitors

1991-03-13

1993-08-31

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

424 851, 424 857, 424 9461, 424408, 424409, 424410, 424422, 424423, 424451, 424456, 424463, 424464, 514 25, 514649, 514659, A01N 2508, A01N 3302, A61K 920, A61K 3113

Patent

active

052407071

ABSTRACT:
Substituted (1.alpha.,2.beta.,3.alpha. or .beta.,4.alpha.,5.alpha. or .beta.)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclopentylamines are inhibitors of alpha-mannosidase and alpha-fucosidase and are useful immunostimulants, antiviral and antimetastatic agents.

REFERENCES:
patent: 4857315 (1989-08-01), Dennis
Sunkara et al. "Antiviral pharmaceuticals containing viral protein glycosylation inhibitors", Pharmaceuticals, 63-6, 1988.
Kino, T. et al., Journal of Antibiotics, vol. 38, No. 7, pp. 936-940 (1985).
White, S. L. et al., Biochemical and Biophysical Research Communications, vol. 150, No. 2, pp. 615-625 (1988).
Winkler, D. A. et al., J. Med. Chem. 32, pp. 2084-2089, (1989).
Myc, A. et al., Cancer Research 49, pp. 2879-2883 (1989).
Dennis, J. W., Cancer Reseearch 46, pp. 5131-5136 (1986).
Hino, M. et al., The Journal of Antibiotics, vol. 38, No. 7, pp. 926-935 (1985).
Yoshikawa, M. et al., Chem. Pharm Bull. 36(9), pp. 3718-3721 (1988).
Bowlin, T. L. et al., Biochemical and Biophysical Research Communications vol. 151, No. 2, pp. 859-864, (1988).
Yoshikawa, M. et al., Chem. Pharm. Bull. 37(2), pp. 545-547 (1989).
McDowell, W. et al., Virology 161, pp. 37-44 (1987).

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