Alpha-ketoglutarates of active ingredients and compositions...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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C424S078310, C560S155000

Reexamination Certificate

active

07728037

ABSTRACT:
Novel stable and pharmacologically acceptable salts of L-carnitine and lower alkanoyl L-carnitines with alpha-ketoglutaric acid are disclosed as well as the compositions useful as dietary and dietetic supplements, nutraceuticals or drugs containing same.

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patent: 4883786 (1989-11-01), Puricelli
patent: 5073376 (1991-12-01), Kohl et al.
patent: 5270297 (1993-12-01), Paul et al.
patent: 5292538 (1994-03-01), Paul et al.
patent: 5817329 (1998-10-01), Gardiner
patent: 199 29 993 (2001-01-01), None
Berge et al. “Pharmaceutical salts” J. Pharm. Sci. 66(1) p. 1-19 (1977).
Guarnieri et al , “Carnitine metabolism in uremia” CA 136:276784 (2001).
Jordaan et al, “Pharmaceuticals and nutritional . . . ” CA 142:379275 (2004).
Mountcastle “Medical Physiology” Mosbey Co., p. 847-848 (1968).

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