.alpha.-ketoamide multicatalytic protease inhibitors

Details .alpha.-ketoamide multicatalytic protease inhibitors .alpha.-ketoamide multicatalytic protease inhibitors

1998-10-06

2000-08-01

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548546, 558303, 554 56, 564159, C07D20948, C07C25503, C07C23305, C07C23318

Patent

active

060967781

ABSTRACT:
This invention relates to .alpha.-ketoamide inhibitors of multicatalytic protease (MCP), to compositions including such inhibitors, and to methods for the use of MCP inhibitors. The MCP inhibitors of the present invention are useful, for example, to retard loss of muscle mass incident to various physiological states.

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