Alpha ketoamide compounds as cysteine protease inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C564S154000, C546S333000, C514S357000, C514S616000

Reexamination Certificate

active

07488848

ABSTRACT:
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

REFERENCES:
patent: 6420364 (2002-07-01), Emmanuel et al.
patent: 6506733 (2003-01-01), Buysse et al.
patent: 6730671 (2004-05-01), Cywin et al.
patent: 2003/0092634 (2003-05-01), Buysse et al.
patent: 2004/0127426 (2004-07-01), Graupe et al.
patent: 2005/0014941 (2005-01-01), Black et al.
patent: 2005/0182096 (2005-08-01), Link et al.
patent: 2005/0240023 (2005-10-01), Bayly et al.
patent: 2006/0111440 (2006-05-01), Gauthier et al.
patent: 0 623 627 (1994-11-01), None
patent: WO 99/24460 (1999-05-01), None
patent: WO/00/51998 (2000-09-01), None
patent: WO 00/55125 (2000-09-01), None
patent: WO/00/55144 (2000-09-01), None
patent: WO/01/19796 (2001-03-01), None
patent: WO/01/19816 (2001-03-01), None
patent: WO 01/49288 (2001-07-01), None
patent: WO 01/68645 (2001-09-01), None
patent: WO 02/20485 (2002-03-01), None
patent: WO/02/069901 (2002-09-01), None
patent: WO 02/074904 (2002-09-01), None
patent: WO 02/098850 (2002-12-01), None
patent: WO/03/024924 (2003-03-01), None
patent: WO/03/029200 (2003-04-01), None
patent: WO 03/075836 (2003-09-01), None
patent: WO/03/097617 (2003-11-01), None
patent: WO 03/097617 (2003-11-01), None
patent: WO 2004/083182 (2004-03-01), None
patent: WO/2004/033445 (2004-04-01), None
patent: WO/2004/108661 (2004-12-01), None
patent: WO 2005/021487 (2005-03-01), None
patent: WO 2005/028429 (2005-03-01), None
patent: WO/2005/028454 (2005-03-01), None
patent: WO 2005/040142 (2005-05-01), None
patent: WO/2005/058348 (2005-06-01), None
patent: WO/2005/063742 (2005-07-01), None
patent: WO/2005/074904 (2005-08-01), None
patent: WO/2006/034004 (2006-03-01), None
Bundgaard, et al. “A Novel Solution-Stable, Water-Soluble Prodrug Type for Drugs Containing a Hydroxyl or an NH-Acidic Group,” J. Med. Chem., 19898, vol. 32, No. 12, pp. 2503-2507.
Greenspan, et al. Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design, J. Med. Chem., 2001, vol. 44, pp. 4524-4534.
Gong, Y., et al., “Convenient Substitution of Hydroxypyridines with Trifluoroacetaldehyde Ethyl Hemiacetal,” Journal of Heterocyclic Chemistry 2001, vol. 38, No. 1, p. 25-28.
Volonterio, et al., “Solution/solid-phase synthesis of partially modified retro-ψ [NHCH(CF3)]- peptidyl hydroxamates”, Tetrahedron Letters, 2001, vol. 42, pp. 3141-3144.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Alpha ketoamide compounds as cysteine protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alpha ketoamide compounds as cysteine protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alpha ketoamide compounds as cysteine protease inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4087153

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.