.alpha.-keto amide derivatives

Details .alpha.-keto amide derivatives .alpha.-keto amide derivatives

1991-07-12

1993-06-22

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548518, C07D20708

Patent

active

052217523

ABSTRACT:
The present invention discloses a new .alpha.-keto amide derivative or a salt thereof represented by the formula (1): ##STR1## wherein X represents (1) a peptide residue or amino acid residue in which the functional group may be protected, (2) a hydrogen atom or (3) an amino-protective group, Y represents a peptide residue or amino acid residue in which the functional group may be protected, E represents a substituent on the alkylene (C.sub.n H.sub.2n-1) and is a halogen, lower alkoxy or hydrogen, A represents a carbonyl group or mono- or di-substituted methylene (the substituent being a hydroxy, lower alkoxy, phenylimino or benzylimino), and n represents an integer of 2 to 6.
The compound of the present invention is effective in inhibiting prolyl endopeptidase activity and useful as an active ingredient of an enzyme inhibitor.

REFERENCES:
Toda, et al., C.A. 113:23894k (1989).
Henning, et al., C.A., 112:76705g (1989).
Igarashi, et al., C.A., 92:42341s (1979).

Affiliated with

Also associated with

Rating

.alpha.-keto amide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .alpha.-keto amide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.-keto amide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1441988