.alpha. hydroxy tripeptide substrates

Details .alpha. hydroxy tripeptide substrates .alpha. hydroxy tripeptide substrates

1979-12-03

1981-01-13

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435 4, 435 14, C07C10352, C07G 700

Patent

active

042448654

ABSTRACT:
This invention relates to the synthesis and use of novel .alpha. hydroxy tripeptide substrates which are useful in the quantitative determination of proteolytic enzymes such as thrombin and trypsin. In use, the disclosed substrates are hydrolyzed by a proteolytic enzyme to yield a moiety that can be evaluated spectrophotometrically to indicate the quantity of enzyme present.

REFERENCES:
patent: 4028318 (1977-06-01), Aurell et al.
patent: 4061625 (1977-12-01), Ekenstam et al.
patent: 4070245 (1978-01-01), Svendsen
patent: 4137225 (1979-01-01), Ekenstam et al.

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