Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Calorimeter
Patent
1989-11-17
1991-08-27
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Calorimeter
436135, 436166, 436169, 436904, 568560, 568563, 568564, C01N 2118
Patent
active
050431420
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to .alpha.-hydroperoxyisopropylphenyl compounds and a process for preparing the same.
Furthermore, the invention is concerned with test compositions for the measurement of peroxide-active substances using as organic hydroperoxide the above-mentioned .alpha.-hydroperoxyisopropylphenyl compounds and test devices carrying said compositions.
The .alpha.-hydroperoxyisopropylphenyl compounds and the compositions or test devices containing the same are effectively utilized for detecting peroxide-active substances such as blood or hemoglobin.
It may be presumed that if blood or hemoglobin is contained in urine, feces or vomit, certain disease such as inflammation or ulcer progresses in the urinary organs or the digestive system such as the kidneys, the stomach or the intestines. Therefore, in order to promptly diagnose and treat such disease correct detection of blood or hemoglobin (occult blood) in urine, feces or vomit as mentioned above is important. The .alpha.-hydroperoxyisopropylphenyl compounds of the invention are favorably used as a reagent for the examination of such occult blood.
BACKGROUND ART
Test devices for the detection of occult blood are constituted of a carrier in which organic hydroperoxide, coloration indicator, buffering agent, wetting agent, activating agent and stabilizer are impregnated. If hemoglobin is present in a specimen, the organic hydroperoxide is activated to produce nascent oxygen with which the indicator is oxidized and develops color. As the organic hydroperoxide are known 2,5-dimethylhexane-2,5-dihydroperoxide and cumene hydroperoxide. Whereas these peroxides are in practical use, they are disadvantageous in remarkably reducing of the detective sensitivity due to lack of stability with elapse of time, pseudonegative judgement when vitamin C is contained in the urine specimen, reduction of capacity in the multi-item test pieces for the detection of urinary components caused by discoloration of the adjacent test pieces, low coloration sensitivity, etc. Compounds in which the benzene ring of cumene hydroperoxide is provided with a substituent such as a C.sub.1-6 alkyl group, Cl, Br, I, NO.sub.2 or carboxyl group have recently been proposed as the hydroperoxide with which these disadvantages are improved (Japanese Patent LOP Publication No. 190663/1984). Although the peroxides represent considerable improvement over the known compounds, the stability with elapse of time is not yet satisfactory.
DISCLOSURE OF THE INVENTION
First, it is an object of the invention to provide peroxides without the above-mentioned disadvantages and a process for preparing the same.
Second, another object of the invention is to provide test compositions for the measurement of peroxide-active substances without the above-mentioned disadvantages and test devices carrying the same.
These objects are achieved by the present invention as set forth below.
(1) An .alpha.-hydroxyperoxyisopropylphenyl compound having the general formula (I) or (II) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and respectively represent hydrogen atom, a lower alkyl group, a halogen atom, carboxyl group, nitro group or a straight- or branched-chain oxygen-containing alkyl group having one or more ether bonds in the chain or a monovalent organic group containing sulfur atom provided that at least one of R.sup.1, R.sup.2 and R.sup.3 represents the above-mentioned straight- or branched-chain oxygen-containing alkyl group or a monovalent organic group containing sulfur atom; X represents a straight- or branched-chain alkylene group which may contain ether bond and/or phenylene group in the chain or a divalent organic group containing sulfur atom and R.sup.4 and R.sup.5 are the same or different and respectively represent hydrogen atom, a lower alkyl group, a halogen atom, carboxyl group or nitro group.
(2) A compound of the formula (I) according to item 1 wherein the oxygen-containing alkyl group in R.sup.1 -R.sup.3 is a group having 2-100 carbon atoms.
(3
REFERENCES:
patent: 4326088 (1982-05-01), Braus
Fujii Katsuya
Ichikawa Syuji
Nomura Takeo
Collins Laura E.
Terumo Kabushiki Kaisha
Warden Robert J.
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