Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-17
1992-05-12
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514341, A61A 31415
Patent
active
051128454
ABSTRACT:
The invention is concerned with aromatase inhibiting compounds of formula I ##STR1## wherein R and Ro represent hydrogen or lower alkyl; or R and Ro located on adjacent carbon atoms and together when combined with the benzene ring to which they are attached form a naphthalene or tetrahydronaphthalene ring; R.sub.1 and R.sub.2 independently represent hydrogen, lower alkyl, (lower alkyl, aryl or aryl-lower alkyl)-thio, lower alkenyl, aryl, aryl-lower alkyl, C.sub.3 -C.sub.6 -cycloalkyl, or C.sub.3 -C.sub.6 -cycloalkyl-lower alkyl; or R.sub.1 and R.sub.2 combined represent lower alkylidene, mono- or di-aryl-lower alkylidene; R.sub.1 and R.sub.2 combined also represent C.sub.4 -C.sub.6 -straight chain alkylene, lower alkyl-substituted straight chain alkylene or ortho-phenylene bridged-C.sub.2 -C.sub.4 -straight chain alkylene, each forming with the carbon atom attached thereto a corresponding optionally substituted or benzo-fused 5, 6 or 7-membered ring; W represents 1-imidazolyl, 1-(1,2,4- or 1,3,4)-triazolyl or 3-pyridyl; or W represents 1-imidazolyl, 1-(1,2,4 or 1,3,4)-triazolyl or 3-pyridyl substituted by lower alkyl; and pharmaceutically acceptable salts thereof.
REFERENCES:
patent: 4749713 (1988-06-01), Bowmann et al.
patent: 4755526 (1988-07-01), Hirsch et al.
patent: 4757076 (1988-07-01), Hirsch et al.
patent: 4801594 (1989-01-01), Hirsch et al.
patent: 4866086 (1989-09-01), Boyle et al.
patent: 4916144 (1990-04-01), Strehike et al.
patent: 4937250 (1990-06-01), Bowmann et al.
patent: 4978672 (1990-12-01), Bowmann et al.
patent: 5021434 (1991-06-01), Strehike et al.
Derwent Abstract 91-038641.
J. Med. Chem. vol. 30, 1359 (1987).
Bowman Robert M.
Browne Leslie J.
Diener Robert
Ewald Bruce H.
Steele Ronald E.
Ciba-Geigy Corporation
Fan Jane T.
Gruenfeld Norbert
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