Alpha-heterocyclc substituted tolunitriles

Details Alpha-heterocyclc substituted tolunitriles Alpha-heterocyclc substituted tolunitriles

1988-09-06

1990-12-18

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514333, 514340, 5482622, 546276, 546256, A61K 3141, C07D24908

Patent

active

049786725

ABSTRACT:
The invention is concerned with aromatase inhibiting compounds of formula I ##STR1## wherein R and Ro represent hydrogen or lower alkyl; or R and Ro located on adjacent carbon atoms and together when combined with the benzene ring to which they are attached form a naphthalene or tetrahydronaphthalene ring; R.sub.1 and R.sub.2 independently represent hydrogen, lower alkyl, (lower alkyl, aryl or aryl-lower alkyl)-thio, lower alkenyl, aryl, aryl-lower alkyl, C.sub.3 -C.sub.6 -cycloalkyl, or C.sub.3 -C.sub.6 -cycloalkyl-lower alkyl; or R.sub.1 and R.sub.2 combined represent lower alkylidene, mono- or di-aryl-lower alkylidene; R.sub.1 and R.sub.2 combined also represent C.sub.4 -C.sub.6 -straight chain alkylene, lower alkyl-substituted straight chain alkylene or ortho-phenylene bridged-C.sub.2 -C.sub.4 -straight chain alkylene, each forming with the carbon atom attached thereto a corresponding optionally substituted or benzo-fused 5, 6 or 7-membered ring; W represents 1-imidazolyl, 1-(1,2,4- or 1,3,4)-triazolyl or 3-pyridyl; or W represents 1-imidazolyl, 1-(1,2,4 or 1,3,4)-triazolyl or 3-pyridyl substituted by lower alkyl; and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 3397273 (1968-08-01), Van Heyningen et al.
patent: 3531494 (1970-09-01), Adolphi et al.
patent: 3657445 (1972-04-01), Buchel et al.
patent: 3666862 (1972-05-01), Buchel et al.
patent: 3709901 (1973-01-01), Draber et al.
patent: 3711487 (1973-01-01), Draber et al.
patent: 3764690 (1973-10-01), Draber et al.
patent: 3769422 (1973-10-01), Timmler et al.
patent: 3794653 (1974-02-01), Draber et al.
patent: 3821394 (1974-06-01), Timmler et al.
patent: 3852056 (1974-12-01), Draber et al.
patent: 3897438 (1975-07-01), Draber et al.
patent: 3927017 (1975-12-01), Heeres et al.
patent: 3978069 (1976-08-01), Buchel et al.
patent: 4006243 (1977-02-01), Strehlke et al.
patent: 4140782 (1979-02-01), Timmler et al.
patent: 4182624 (1980-01-01), Soder et al.
patent: 4226878 (1980-10-01), Iizuka et al.
patent: 4238498 (1980-12-01), Regal et al.
patent: 4243670 (1981-01-01), Regel et al.
patent: 4251540 (1981-02-01), Regel et al.
patent: 4281141 (1981-07-01), Merritt et al.
patent: 4396771 (1983-08-01), Thorogood
patent: 4431815 (1984-02-01), Thorogood
patent: 4448781 (1984-05-01), Cross et al.
patent: 4483866 (1984-11-01), Ogata et al.
patent: 4500523 (1985-02-01), Nathanielsz
patent: 4562199 (1985-12-01), Thorogood
patent: 4602025 (1986-07-01), Hirsh et al.
patent: 4605661 (1986-08-01), Hirsh et al.
patent: 4606666 (1986-09-01), Hirsch et al.
patent: 4617307 (1986-10-01), Browne
patent: 4657921 (1987-04-01), Frick et al.
patent: 4659730 (1987-04-01), Hirsch et al.
patent: 4661508 (1987-04-01), Hirsch et al.
patent: 4689341 (1987-08-01), Diamond et al.
patent: 4728645 (1988-03-01), Browne
patent: 4735960 (1988-04-01), Hirsch et al.
patent: 4755526 (1988-07-01), Hirsch et al.
patent: 4757076 (1988-07-01), Hirsch et al.
patent: 4757082 (1988-07-01), Hirsch et al.
patent: 4762836 (1988-08-01), Hirsch
patent: 4764376 (1988-08-01), Hirsch et al.
patent: 4766140 (1988-08-01), Hirsch et al.
patent: 4801594 (1989-01-01), Hirsch et al.
patent: 4866086 (1989-09-01), Boyle et al.
Mason et al, Biochemical Pharmacology, vol. 24, p. 1087 (1985).
Abstract of SU 1355-126A (1987).
Abstract of EP 1060606A (1984).

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