Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1994-05-02
1995-08-29
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530300, 530324, 530330, A61K 3800, C07K 500, C07K 700, C07K 1700
Patent
active
054461286
ABSTRACT:
There are disclosed alpha-helix mimetics and methods relating to the same for imparting or stabilizing alpha-helicity to a peptide or protein. In one aspect, the alpha-helix mimetics contain six- or seven-membered rings covalently attached at the end or within the length of the peptide or protein. The alpha-helix mimetics render the resulting peptide or protein more stable with regard to thermal stability, as well as making the peptide or protein more resistant to proteolytic degredation. In addition, the alpha-helix mimetics may be used in standard peptide synthesis protocols.
REFERENCES:
Hruby et al., Biochem. J., vol. 268, pp. 249-262 (1990).
Huff Sheela J.
The Board of Trustees of the University of Illinois
Warden Jill
LandOfFree
Alpha-helix mimetics and methods relating thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Alpha-helix mimetics and methods relating thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alpha-helix mimetics and methods relating thereto will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1820133