Alpha-helix mimetics and methods relating thereto

Details Alpha-helix mimetics and methods relating thereto Alpha-helix mimetics and methods relating thereto

1995-05-30

1998-01-20

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530350, 530330, 530402, 514 12, A61K 3800, C07K 700, C07K 710

Patent

active

057102457

ABSTRACT:
There are disclosed alpha-helix mimetics and methods relating to the same for imparting or stabilizing alpha-helicity to a peptide or protein. In one aspect, the alpha-helix mimetics contain six- or seven-membered rings covalently attached at the end or within the length of the peptide or protein. The alpha-helix mimetics render the resulting peptide or protein more stable with regard to thermal stability, as well as making the peptide or protein more resistant to proteolytic degredation. In addition, the alpha-helix mimetics may be used in standard peptide synthesis protocols.

REFERENCES:
patent: 5446128 (1995-08-01), Kahn
Hruby et al, Biochem J. vol. 268, pp. 249-262 (1990).
Hruby, Biopolymers, vol. 33, 1073-1082 (1993).
Saragovi et al, Biotechnology, vol. 10, 1992.
Saragovi et al, Immunomethods 1,5-9 (1992).

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