Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1989-04-14
1991-08-13
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
558396, 558438, 548173, 548189, A01N 3734
Patent
active
050397028
ABSTRACT:
Userful as antimicrobial agents in aqeuous systems are .alpha.-halo.beta.-(substituted)thioacrylonitriles of the formula ##STR1## wherein X represents Cl, Br or I and R represents a lower alkyl, aryl, aralkyl, heterocyclo, or a thiocarbonyl group. The configuration about the double bond may be E or Z or a mixture thereof. These compounds provide effective control of microbial growth. The derivatives of formula I are economically prepared from acrylonitrile via a three-step process involving (a) halogenation, (b) dehydrohalogenation and (c) nucleophilic-type displacement. Except for those compounds wherein X is bromo and R is methyl or phenyl, the compounds of formula I are not mentioned in the prior art.
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Brandman Alyce
Manowitz Milton
Rachlin Albert I.
Brust Joseph Paul
Givaudan Corporation
Tavares Robert F.
Vag Linda A.
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